Shift Bioscience has established a management team and board that combines extensive experience in both mitochondrial biology and in the development of successful biotechnology startups.
Daniel Ives is the scientific founder who first discovered the gene shifting targets upon which the Shift drug discovery platform is based. Daniel graduated from Imperial College with a degree in biochemistry in 2009. He gained his PhD in 2013, working at the Walker Lab, Mitochondrial Biology Unit at Cambridge University's Laboratory of Molecular Biology. He carried out his post-doctoral studies under Ian Holt at the National Institute of Medical Research in Mill Hill, now part of the Crick Institute. Daniel is the named inventor on UK patent application 1900697.2 relating to methods of novel treatment of impaired mitochondria.
Romina obtained a Ph.D. degree in Biochemistry at The University of Manchester, and more recently studied for her MSc in Bio-Business at the Birkbeck University, providing a valuable perspective of trends in the pharma and biotech industries.
Romina spent 10 years investigating mitochondrial dysfunction and rare genetic diseases in academia. She uncovered the link between mitochondrial dysfunction and metabolism in WHS syndrome, publishing six papers.
Stephen Ives graduated from the University of Cambridge in 1980 with a degree in Biochemistry and gained an MBA degree in 1982 from the Wharton School at the University of Pennsylvannia. In 1999, he founded Aspective – an early cloud services provider that was later acquired by Vodafone. In 2000 he founded Trigenix, a mobile technology startup which won a number of industry awards and was subsequently acquired in 2004 by Qualcomm.
Jonathan is co-founder and currently Deputy Chairman of Abcam plc. He is an experienced entrepreneur and investor who has assisted three technology companies to IPO on the London AIM market. He identified the market opportunity for supplying high-quality antibodies to support protein interaction studies and, in 1998, founded Abcam with David Cleevely and Tony Kouzarides. Abcam went public in 2005 and by the end of 2010 had reached a market cap of £1 billion.
Jonathan gained his doctorate in Molecular Genetics at Leicester University after graduating in Applied Biology at Bath. From 1992–95, he was a post-doctoral researcher at Bath, following which he worked at the University of Cambridge in the Kouzarides Lab researching the molecular basis of breast cancer.
Prof Wolf Reik is internationally recognised for his fundamental discoveries in epigenetics, including their role in mammalian development, physiology, genome reprogramming, and human diseases. Wolf uncovered the molecular mechanism of genomic imprinting and identified the first multi-tissue epigenetic aging clock in mice. He was awarded the Wellcome Prize in Physiology and is a Fellow of the Royal Society, the Academy of Medical Sciences, and a member of the European Molecular Biology Organisation (EMBO).
Aubrey de Grey is Chief Science Officer of SENS Research Foundation, a California-based biomedical research charity dedicated to combating the aging process. He received his BA in computer science and PhD in biology from the University of Cambridge. Aubrey is also Editor-in-Chief of Rejuvenation Research, the world’s highest-impact peer-reviewed journal focused on intervention in aging. He is a sought-after speaker who gives 40-50 invited talks per year at scientific conferences, universities and companies.
This image is a combination of conventional wide field imaging and the superresolution technique “structured illumination” (max. res. 110nm). The hazy green colors are wide field actin fibers whereas the magenta stains the same by superresolution. Similarly, the nuclear DNA is stained in blue and cyan whereas the mitochondrial network is shown in red and yellow.
Katharina Hellwig, Hocke Lab, Charité – Universitätsmedizin Berlin Dept of Internal Medicine
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